Physiopathology and Sequelae of COVID-19 Infection

Not Applicable

Recruiting

• Conditions: Covid19; Cortisol; TSH

• Registration Number: NCT04563676
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

The data obtained from Covid-19 infections seem to suggest that the immunogenesis of Covid-19 could in some cases be the result of immune dysregulation. On the other hand, endocrine damage is possible at the tile of Covid-19 infection (mainly thyroid,adrenal, and hypothalamus). These disorders are autoimmune or linked to degeneration.

The main objective is to assess the thyroid function (thyrotropic axis) as well as the corticotropic adrenal function of patients who have had Copvid-19 pneumonia. The secondary objectives is to describe the pathophysiological mechanisms of pulmonary and vasculothrombotic involvement of Covid-19

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-22
• Study First Submitted: 2020-09-23
• Study First Submitted QC: 2020-09-23
• Study First Posted: 2020-09-24
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-07
• Last Update Posted: 2023-02-08
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• patient having a covid19 infection hospitalized at the Amiens Picardie University Hospital
• Patient who is seen in Pneumology consultation for a respiratory assessment at 3 months of his hospitalization (between M2 and M4) to evaluate presence of respiratory sequelae
• Patient who agreed to participate in the protocol
• Patient affiliated to a Social Security

Exclusion Criteria

• patient under guardianship or curators
• patient refusing to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
8-hour cortisol level in patients with Covid19 pneumonia	day 0	8-hour cortisol level in patients with Covid19 pneumonia will be determined the day of consultation for respiratory sequelae.
TSH level in patients with Covid19 pneumonia	day 0	TSH level in patients with Covid19 pneumonia will be determined the day of consultation for respiratory sequelae.

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France