Evaluation of a Predictive Score for the Onset of Moderate to Severe Alcohol Withdrawal Syndrome, the PAWSS, in a Population of Intensive Care Patients at Brest University Hospital

Completed

• Conditions: Alcohol Withdrawal Syndrome

• Registration Number: NCT06555679
• Lead Sponsor: University Hospital, Brest

Brief Summary

alcohol use disorder (AUD) is a very common condition in patients admitting in ICU's. Brutal stop of alcohol consumption may lead to a withdrawal syndrome, wich is associated with a worse outcome for ICU patients (longuer ICU and hospital stays, use of mechanical ventilation, traumas). The aim of this study is to valid a score (PAWSS : prediction of alcohol withdrawal syndrome (AWS) scale) to predict at admission mild to severe AWS in ICU patients population.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-27
• Primary Completion: 2023-06-26
• Study Completion: 2023-06-26
• Status Verified: 2024-08
• Study First Submitted: 2024-08-08
• Study First Submitted QC: 2024-08-14
• Last Update Submitted: 2024-08-14
• Study First Posted: 2024-08-15
• Last Update Posted: 2024-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 403

Inclusion Criteria

• more than 18 years old
• able to answer to PAWSS in the first 48hours of ICU stay

Exclusion Criteria

• No alcohol consumption in the last 30 days
• hospital stay of more than 5 days at ICU admission
• hospital stay less than 5 days in total
• expected sedation time of more than 48h
• patient not able to understand the PAWSS
• no consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of PAWSS statistic performances to predict AWS in ICU patients	the first 5 days of hospital stay	Evaluation of sensitivity, specificity, positive and negative predictive values of PAWSS to predict moderate or severe AWS (defined by a CIWA greater than or equal to 8)

Secondary Outcome Measures

Name	Time	Method
Creation of a new score, the PAWSS-ICU, able to predict AWS in ICU patients	during ICU stay	To this end, the characteristics of the \[no weaning/minimal weaning\] and \[moderate weaning/severe weaning\] groups will be compared, in order to identify significant differences between these two groups, and thus enable the creation of a new score.; On an exploratory basis : * assess the incidence of alcohol misuse and withdrawal syndrome in our population,; * assess the incidence of complications in the population with moderate to severe withdrawal (trauma, occurrence of pneumopathy, need for mechanical ventilation),; * assess length of hospital stay and in-hospital mortality.; Translated with DeepL.com (free version)

Trial Locations

Locations (1)

CHRU Brest; 🇫🇷 Brest, France