Influence of a 4-week combined strength and endurance training in post-covoid patients with chronic performance reduction and fatique symptoms - pilot study

Not Applicable

• Conditions: U07.1; U09.9; COVID-19, virus identified; Post COVID-19 condition, unspecified

• Registration Number: DRKS00026686
• Lead Sponsor: Klinik und Poliklinik für Kardiologie am Universitätsklinikum Leipzig

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-27
• Study Completion: 2023-03-01
• Results First Posted: 2023-09-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

Patients with persistent fatigue after cured COVID-19 disease min. 6 weeks, MFI > 50 min 4/5 areas affected
- Post-Covid Functional Scale ± 2
- Normal LVEF
- Nt-pro-BNP, troponin T in normal range
- FEV1 and FVC within normal range

Exclusion Criteria

- Known underlying pulmonary or cardiac disease defined as heart failure with preserved or reduced pump function, myocarditis, known coronary artery disease, obstructive restrictive lung disease.
- COVID-19 conditional cardiovascular complication e.g. pulmonary embolism, pulmonary fibrosis, myocardial infarction, myocarditis.
- Lack of consent
- Pregnancy
- Age<18 years

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Subjective improvement in perceived fatigue according to MFI-20 in at least 2 of 5 categories at follow-up (1st/3rd/6th month)

Secondary Outcome Measures

Name	Time	Method
- VO2 max., O2 pulse <br>- Improvement in quality of life according to McGill Quality of Life Questionnaire (MQOL) <br>- Improvement in Post-Covid-Functional-Scale <br>- 1-RM (Repetition maximum) - Strength performance<br>- Leisure time activity (Physical activity Assessment) <br>- Cardiac enzymes, CBC, NLRP3 inflammasome, inflammatory parameters<br><br>1st month follow-up, questionnaires also 3rd month and 6th month