Investigation of the anti-inflammatory effects of heparin in mechanically ventilated patients
Phase 3
- Conditions
- Mechanical Ventilation.Other postprocedural respiratory disorders
- Registration Number
- IRCT201701011497N6
- Lead Sponsor
- Vice Chancellor for Research,Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients who require invasive mechanical ventilation for more than 48 hours.
Exclusion criteria:If patients receive mechanical ventilation for more than 24 hours prior to enrollment; has required mechanical ventilation for more than 48 hours in previous admission in ICU during the current hospital admission; allergy to heparin (including any history of heparin-induced thrombocytopenia); a pulmonary hemorrhage in the previous 3 months; uncontrolled bleeding or a significant bleeding disorder; an intracranial hemorrhage in the past 12 months; or an epidural catheter in place or likely to be placed in the next 48 hours and are younger than 18 years old.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in ratio of partial pressure of oxygen to FiO2 (PaO2/FiO2). Timepoint: during the 5 days of study. Method of measurement: ratio of PaO2/FiO2.
- Secondary Outcome Measures
Name Time Method (RSBI)RAPID SHALLOW BREATHING INDEX. Timepoint: during 5 days of study. Method of measurement: ratio of tidal volume to respiratory rate.