Conventional bronchoscopy vs. endosonography: A randomized prospective clinical study for the diagnosis of sarcoidosis

Recruiting

• Conditions: Besnier-Boeck disease; lekenterm nvt; 10027665; 10024967

• Registration Number: NL-OMON33798
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

Patients with suspected pulmonary sarcoidosis (stage I/II) in whom a tissue diagnosis
(presence of non-caseating granulomas) is indicated.

Exclusion Criteria

No informed consent
Unable to undergo EUS/EBUS or bronchoscopy (e.g. esophageal strictures, respiratory insufficency)
Unable to participate in the follow -up
Contraindications for a lung or nodal biopsy (e.g. coagulopathy, thrombocytopenia)
Pregnancy
age under 18 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The sensitivity of endo-sonography vs. bronchoscopy in the detection of<br /><br>non-caseating granulomas.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. The role of a broncho-alveolar lavage (BAL) in addition to endo-sonography<br /><br>and conventional bronchoscopy for diagnosing sarcoidosis.<br /><br><br /><br>2. Complications in both study arms.<br /><br><br /><br>3. Patient tolerance for both study arms.</p><br>