Endobronchial vs. esophageal ultrasound for diagnosing sarcoidosis: A randomized clinical trial;<br>A standard vs ProCore Needle compariso

Completed

• Conditions: sarcoisosis; 10013369

• Registration Number: NL-OMON45012
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Clinical and radiologic suspicion of sarcoidose stage I (mediastinal or hilar lymphadenopathy) or stage II (lymphadenopathy and interparenchymal abnormalities);
Indication for tissue verification of noncaseating granuloma*s;

Exclusion Criteria

Life expectancy less than 6 months;
Obvious organ involvement of sarcoidosis with the possibility to confirm granulomas with a minimally invasive diagnostic procedure (eg skin lesion or superficial lymph node);
Positive acid-fast bacilli sputum test;
Contra-indication for endosonography;
Under 18 years of age;
Pregnancy;

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The granuloma detection rate of endobronchial (EBUS) guided sampling of<br /><br>intrathoracic lymph nodes compared to esophageal (EUS-B using the EBUS<br /><br>scope) guided sampling in patients with suspected sarcoidosis stage I/II.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Sensitivity of EBUS-TBNA for diagnosing sarcoidosis;<br /><br><br /><br>Sensitivity of EUS-B-FNA for diagnosing sarcoidosis;<br /><br><br /><br>Granuloma detection rate of the conventional 22G needle and 25G ProCore neelde;<br /><br><br /><br>Complications;</p><br>