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临床试验/NCT05485285
NCT05485285已完成不适用

Peculiarities of Pain in Patients With Mine-explosive Wounds Depending on the Localization of the Wound at the Stages of Treatment

Bogomolets National Medical University1 个研究点 分布在 1 个国家目标入组 660 人开始时间: 2022年2月24日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
660
试验地点
1
主要终点
The Hospital Anxiety and Depression Scale

研究概览

简要总结

Mine-explosive wounds in the general structure of combat sanitary losses reach 25%. They are characterized by significant damage resulting in high intensity pain. In patients who received mine-explosive injuries in the conditions of hostilities, such pain has its own unique features. It is necessary to pay more attention to the problem of pain treatment in patients of this category, because about 87.2% of cases have negative results of treatment - it becomes chronic.

详细描述

Over the last ten years, the amount of pathology caused by mine-explosive devices has increased significantly. Mine-explosive wounds in the general structure of combat sanitary losses reach 25%. They often have a combined character. Such an injury must be considered as a multifactorial injury resulting from the combined impact on a person of a shock wave, gas jets, flames, toxic products, fragments of the hull, secondary projectiles, which cause severe injuries in the area of direct damage and the body as a whole. Mine-explosive injuries are characterized by multiple, combined or combined injuries with a high degree of severity - 8-10%. Also, even in peacetime, terrorists often use powerful explosive devices. Here, the mortality rate is 10-20% of the total number of injured, and 80-90% suffer from the consequences - mine-explosive injuries. Compared to the wars of the past, the number of seriously wounded with combined injuries has increased to 25-30%. This is primarily due to the use of high-precision ammunition and mine-explosive ammunition. In general, multiple and combined damage in local conflicts today is 25-62%. Lethality in case of mine-explosive injury reaches 37-41.4%. The mortality rate among the wounded with mine-explosive injuries who were admitted to the stage of qualified medical care was 17.4%, more than half of the wounded died as a result of blood loss. In 63.7%, death occurs in the first 24 hours after injury.The direct and most frequent causes are shock and blood loss (49.1%), destruction of vital organs (28.4%). About 90% of all combat deaths occur before the wounded reaches the first stage of treatment.

The peculiarities of pain in patients with mine-explosive wounds depending on the localization of the wound at the stages of treatment need to be studied, because the subjective feelings and emotional experiences experienced by patients during the wounding in combat conditions through the prism of psychological disorders have their own characteristics. Since in 87.2% of cases it is not possible to achieve a positive result of treatment, the data of our study will play an important role in their treatment.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Other

入排标准

性别
Male
接受健康志愿者

入选标准

  • the presence of gunshot wounds

排除标准

  • no gunshot wounds

结局指标

主要结局

The Hospital Anxiety and Depression Scale

时间窗: 12 months

0-7 is the norm 8-13 - mild depressive disorders 14-18 - depressive disorders of medium severity 19-22 - severe depressive disorders 23 and more - depressive disorders of a very severe degree of severity

visual analog scale

时间窗: 12 months

from 0 to 10 points

Chaban Quality of Life Scale

时间窗: 12 months

up to 56 inclusive - a very low level 57-66 - low 67-75 - average 76-82 - tall 83-100 is very high

Mississippi PTSD scale (military version)

时间窗: 12 months

the mean values of the total score are 76±18 for well-adjusted servicemen, 86±26 for servicemen with mental disorders, and 130±18 for those with PTSD

Didier Bouhassiraa DN4

时间窗: 12 months

4 or more points (a neuropathic pain component is present)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Vasyl' Horoshko

Chief researcher

Bogomolets National Medical University

研究点 (1)

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