Neural Correlates of Knee Sensorimotor Control in Patients With Patellofemoral Pain Syndrome

Not Applicable

Completed

• Conditions: Patellofemoral Pain Syndrome; Patellofemoral Pain
• Interventions: Other: Neural Imaging

• Registration Number: NCT04099004
• Lead Sponsor: Emory University

Brief Summary

This study aims to determine the neural correlates of knee motor control in young females with patellofemoral pain (PFP). Each participant will attend a single study visit which may last up to 3 hours.

Detailed Description

Patellofemoral pain (PFP) is one of the most common reported knee conditions in adolescents and young adults. PFP can affect nearly 30% of young adults and most frequently affect those who participate in athletic activities involving running, jumping, and cutting. Pain during movement also adversely influences patellofemoral joint loading as evidenced by increased frontal and transverse plane hip motion during activities of daily living. While the biomechanical and anatomical components contributing to knee pain have been well established, the underlying neural mechanisms are less understood. For adults with chronic pain (e.g., osteoarthritis), patients often exhibit greater 'pain network (e.g., anterior cingulate cortex, thalamus)' activation during sensory testing relative to healthy controls, possibly due to long term peripheral receptor activation resulting in hypersensitivity. Further, inducing pain (e.g., pressing on a thumbnail) results in similar neural activation of the pain network for those who have chronic pain symptoms.

While these studies have been imperative to the understanding of pain on neural functioning, they are limited to those specific populations (e.g., fibromyalgia, osteoarthritis) and do not adequately replicate the pain experienced during daily activities. Traditional approaches consisting of bracing and physical therapy focused on strengthening the knee extensors have been unsuccessful in reducing pain. Further, interventions consisting of exercise therapy have not been effective for all patients with PFP, and other pain-reduction techniques, such as direct electrical stimulation of the motor cortex, have failed to produce improved motor function or long-lasting pain relief. The researchers of this study hypothesize that this is due to the failure to appropriately challenge the full sensorimotor network involved in processing sensory and cognitive stimuli for motor control. To effectively treat pain and manage this condition, the neural correlates of pain and sensorimotor knee control in those with PFP is needed.

To appropriately assess the pain network for those with PFP, replicating knee and hip motion while neural function is measured is needed. The research team has successfully developed a combined knee and hip extension and flexion task that can be used safely with functional magnetic resonance imaging (fMRI). The researchers hypothesize that those with PFP will display depressed sensorimotor activity and increased pain network activity during the knee and hip flexion and extension task relative to previously collected data.

The study visit will consist of one magnetic resonance imaging (MRI) session using a GE SIGNA™ Premier 3.0 Tesla MR scanner. The MRI portion of the study visit will be completed in 75 minutes or less, and the entire visit will last up to 3 hours.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2017-11-16
• Study First Submitted: 2019-04-11
• Study First Submitted QC: 2019-09-19
• Study First Posted: 2019-09-23
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-12
• Last Update Posted: 2024-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• Diagnosed with patellofemoral pain (PFP) or anterior knee pain by a medical professional
• Able to provide written consent

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Exclusion Criteria

• Any contraindications to MRI

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Neural Imaging	Neural Imaging	Females with PFP attending a single study visit where neural imaging is acquired via MRI.

Primary Outcome Measures

Name	Time	Method
Blood Oxygen Level Dependent (BOLD) Signal During Quadriceps Contraction	Day 1 (during MRI session)	Brain activity while participants complete a a quadriceps contraction task will be assessed as the BOLD signal obtained using fMRI. For the quadriceps contraction task, participants are asked to 'squeeze' their quadriceps while keeping the rest of their body still.
Blood Oxygen Level Dependent (BOLD) Signal During Flexion/Extension Movement	Day 1 (during MRI session)	Brain activity while participants complete a combined knee and hip flexion/extension movement will be assessed as the BOLD signal obtained using fMRI.
Resting State Blood Oxygen Level Dependent (BOLD) Signal	Day 1 (during MRI session)	Brain activity while the participant is lying still will be assessed as the BOLD signal obtained using fMRI.
Blood Oxygen Level Dependent (BOLD) Signal During Pain Inducing Tasks	Day 1 (during MRI session)	Brain activity while participants complete pain inducing tasks will be assessed as the BOLD signal obtained using fMRI. The pain inducing tasks involve the researcher placing one hand above the participants' knee and applying intermittent pressure to their quadriceps and medial aspect of the patella.

Secondary Outcome Measures

Name	Time	Method
Anterior Knee Pain Scale (AKPS) Score	Day 1 (during MRI session)	Perceived movement dysfunction and disability related to knee pain is assessed using the Anterior Knee Pain (AKPS) scale. The AKPS has 13 items that are scored on scales of 0 to 5 or 0 to 10. Total scores range from 0 to 100 with 100 indicating the best knee function possible.
International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form Score	Day 1 (during MRI session)	Perceived movement dysfunction and disability related to knee pain is assessed using the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form. The IKDC is a 10-item, patient-completed tool which contains sections on knee symptoms, knee function, and sports activities. Scores range from 0 points (lowest level of function or highest level of symptoms) to 100 points (highest level of function and lowest level of symptoms).
Tampa Scale of Kinesiophobia (TSK) Score	Day 1 (during MRI session)	Participant perceived movement dysfunction and disability related to knee pain is assessed using the Tampa Scale of Kinesiophobia (TSK). The TSK is a 17-item questionnaire assessing the fear of movement and re-injury. Responses are given on a 4-point Likert scale where 1 = strongly disagree and 4 = strongly agree. Total scores range from 14 to 68 where higher scores indicate greater concern of re-injury.
Pain Scale Score	Day 1 (during MRI session)	Participants reporting experiencing pain lasting longer than several days in the past two weeks complete a 4-item survey rating current, average, lowest and highest pain levels. Responses are given on a 5-point scale where 1 = no pain and 5 = worst pain possible. Total scores range from 4 to 20 and higher scores indicate greater pain.

Trial Locations

Locations (2)

Cincinanti Childrens Hospital Medical Center (CCHMC); 🇺🇸 Cincinnati, Ohio, United States

Emory Healthcare Sports Performance And Research Center (SPARC); 🇺🇸 Flowery Branch, Georgia, United States