NCT00371982终止不适用
Effect of Fish Oil on Adiposity and Atherogenic Factors in Type 2 Diabetic Women
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- The effect of 2 month treatment on:
研究概览
简要总结
- whether the intake of n-3 PUFA has additional effects on insulin sensitivity and adiposity (total fat mass and adipocyte morphology and function) in T2D women.
- n-3 PUFA supplementation might influence inflammatory genes expression in the adipose tissue of T2D patients.
详细描述
Thus, the present study was designed to evaluate the effects of n-3 PUFAs dietary supplementation on lipid and glucose homeostasis and to address the impact of this treatment on adiposity and adipose tissue gene expression in T2D women.A total of 27 T2D women (BMI 27-35kg/m², age 40-60 y) were randomly allocated to two months of 3 g/day of either fish oil (1.8 g n-3 PUFA) or placebo (paraffin oil), in a double-blind parallel design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetic postmenopausal women
- •glycaemia of 7.87-14.0 mmol/l, HbA1c of 7 to 10.5%
- •plasma triglycerides between 1.72-4.6 mmol/l,
- •aged between 40 -60,
- •BMI: 27-40 kg/m2
- •able to swallow tablets
排除标准
- •patients with abnormal renal, hepatic and thyroid functions as determined by physical examination, blood cell count and standard blood biochemical profile
- •patients with gastrointestinal disorders
- •patients treated with thiazolidinediones or insulin
结局指标
主要结局
The effect of 2 month treatment on:
adiposity (total fat mass, adipocyte morphology), atherogenic markers and insulin sensitivity
次要结局
- the underlying mechanisms of the observed results and tried to define new targets of fish oil metabolic effects
- and the impact of fish oil on systemic inflammatory markers and adipose tissue inflammatory genes.
研究者
研究点 (2)
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