Effects of Nicotinamide Riboside on Metabolic Health in (Pre)Obese Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Insulin sensitivity: muscle- and liver specific
研究概览
简要总结
This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity. Secondary objectives, to provide information about the underlying mechanism, will be muscle mitochondrial function, brown fat activity, ectopic lipid accumulation, energy metabolism, cardiovascular risk parameters, body composition and acetylcarnitine levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent
- •Caucasian
- •Males and postmenopausal females
- •Aged 45-65 years at start of the study
- •Body mass index (BMI) 27 - 35 kg/m2
- •Stable dietary habits (no weight loss or gain >5kg in the past 3 months)
- •Sedentary lifestyle (not more than 2 hours of sports per week)
排除标准
- •Type 2 diabetes
- •Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- •Contra-indication for MRI
- •Participation in earlier research or medical examination that included PET/CT scanning
- •Alcohol consumption of >2 servings per day
- •Smoking in the past 6 months
研究组 & 干预措施
Nicotinamide Riboside
Supplementation of Nicotinamide Riboside (Niagen) of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.
干预措施: Nicotinamide Riboside (Niagen) (Dietary Supplement)
Nicotinamide Riboside
Supplementation of Nicotinamide Riboside (Niagen) of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.
干预措施: Placebo (Dietary Supplement)
Placebo
Supplementation of Placebo of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.
干预措施: Nicotinamide Riboside (Niagen) (Dietary Supplement)
Placebo
Supplementation of Placebo of 1000 mg/day for 6 weeks. 2 capsules in the morning together with breakfast and 2 capsules around noon together with lunch. Each capsule contains 250 mg.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Insulin sensitivity: muscle- and liver specific
时间窗: 6 weeks after supplementation
Hyperinsulinemic euglycemic clamp: Rate of glucose disappearance (Rd) will be calculated by using tracer kinetics.
次要结局
- Body composition(6 weeks after supplementation)
- Muscle mitochondrial function (ex vivo)(6 weeks after supplementation)
- Ectopic lipid accumulation(6 weeks after supplementation)
- Brown adipose tissue activity(6 weeks after supplementation)
- Cardiovascular risk parameters(6 weeks after supplementation)
- Whole body energy expenditure(6 weeks after supplementation)
- Acetylcarnitine levels(6 weeks after supplementation)