Effects of Nicotinamide Riboside on Metabolism and Vascular Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- NAD+
研究概览
简要总结
The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
详细描述
The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
I single investigator will be responsible for blinding. All researchers involved in collection and evaluation of data will remain blinded to treatments.
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 to 35 (young) and 60 to 75 (older)
- •Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
- •Non-smokers
- •Able to give informed consent and participate in all laboratory visits
排除标准
- •Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
- •Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
- •Food allergies to egg, milk, soy or wheat
- •Women who are pregnant or planning to become pregnant during the course of the study,
- •Pacemaker or other implanted device
- •Unwilling to participate in the experimental protocol or blood draws will be excluded
研究组 & 干预措施
Nicotinamide Riboside Chloride (Niagen)
7 days of nicotinamide riboside supplementation (250 mg/d x 2/day).
干预措施: Nicotinamide riboside chloride (Niagen) (Dietary Supplement)
Placebo
7 days of placebo supplementation (2/day)
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
NAD+
时间窗: 7 days
Blood and peripheral blood mononuclear cell (PBMC) levels
次要结局
- Lipdemia(7 days)
- Vasodilatory responsiveness(7 days)
- Oxidative stress and inflammation(7 days)
研究者
Rudy Valentine
Assistant Professor
Iowa State University