Effects of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation in Athletes With Patellar Tendinopathy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- VISA-P Score
研究概览
简要总结
This randomized, double-blind, placebo-controlled clinical trial evaluates the effects of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation combined with an eccentric exercise and extracorporeal shockwave rehabilitation program on pain, tendon morphology, and neuromuscular performance in athletes with patellar tendinopathy.
Thirty athletes with a confirmed diagnosis of patellar tendinopathy are randomized to receive either HMB supplementation (3 g/day) or placebo during an 8-week rehabilitation program. Participants are evaluated at baseline, week 4, and week 8.
The primary outcome is pain and functional limitation assessed using the Victorian Institute of Sport Assessment-Patella (VISA-P) questionnaire. Secondary outcomes include patellar tendon thickness measured by ultrasound imaging, countermovement jump (CMJ) performance, and neuromuscular performance variables derived from an incremental squat test using a linear position transducer.
The aim of the study is to determine whether HMB supplementation enhances clinical recovery and neuromuscular performance when combined with a standardized rehabilitation program compared with placebo.
详细描述
Patellar tendinopathy is a degenerative tendon disorder frequently observed in athletes involved in jumping and running sports. The condition is characterized by localized tendon pain, functional impairment, and structural alterations of the patellar tendon. Standard rehabilitation programs commonly include eccentric exercise protocols and extracorporeal shockwave therapy to promote tendon adaptation and pain reduction.
Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the amino acid leucine, has been associated with anti-catabolic effects and improved muscle recovery. HMB supplementation may potentially enhance neuromuscular adaptations and recovery during rehabilitation programs.
This study evaluates the effects of HMB supplementation when combined with a standardized rehabilitation program including eccentric exercise and extracorporeal shockwave therapy in athletes with patellar tendinopathy.
This randomized, double-blind, placebo-controlled clinical trial includes 30 athletes aged 18 to 49 years with clinically diagnosed patellar tendinopathy. Participants are randomly assigned to one of two groups:
HMB Group: Participants receive oral HMB supplementation (3 g/day) combined with eccentric exercise and extracorporeal shockwave therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind study. Both participants and investigators were unaware of group assignment (HMB or placebo). Capsules were identical in color and appearance, and the allocation code was not disclosed until all data were collected.
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 49 years
- •Clinical diagnosis of patellar tendinopathy confirmed by a physician and physiotherapist
- •Competitive athlete in sports involving repetitive knee loading (e.g., basketball, volleyball, handball, athletics)
- •Minimum training frequency of three sessions per week
- •No knee surgery within the previous 12 months
- •No nutritional supplementation within the previous 3 months
- •No injection therapy (analgesics or platelet-rich plasma) within the previous 12 months
- •Non-smoker
- •Signed informed consent
排除标准
- •Any musculoskeletal injury other than patellar tendinopathy affecting performance
- •Systemic disease affecting musculoskeletal function
- •Inability to comply with the rehabilitation or supplementation protocol
研究组 & 干预措施
HMB Supplement + Rehabilitation Program
Participants receive beta-hydroxy-beta-methylbutyrate (HMB) supplementation in combination with a rehabilitation program consisting of eccentric exercise and extracorporeal shock wave therapy.
干预措施: Eccentric exercise and extracorporeal shock wave therapy (Other)
HMB Supplement + Rehabilitation Program
Participants receive beta-hydroxy-beta-methylbutyrate (HMB) supplementation in combination with a rehabilitation program consisting of eccentric exercise and extracorporeal shock wave therapy.
干预措施: Beta-hydroxy-beta-methylbutyrate (HMB) (Dietary Supplement)
Placebo + Rehabilitation Program
Participants receive placebo supplementation in combination with a rehabilitation program consisting of eccentric exercise and extracorporeal shock wave therapy.
干预措施: Eccentric exercise and extracorporeal shock wave therapy (Other)
结局指标
主要结局
VISA-P Score
时间窗: Baseline (PRE), Week 4 (INT), and Week 8 (POST)
Change in pain and functional limitation assessed using the Victorian Institute of Sport Assessment-Patella (VISA-P) questionnaire. Scores range from 0 to 100, with higher scores indicating better function and lower pain levels.
次要结局
- Patellar tendon thickness(Baseline (PRE), Week 4 (INT), and Week 8 (POST))
- Countermovement Jump (CMJ)(Baseline (PRE), Week 4 (INT), and Week 8 (POST))
- Peak Power (PP) during squat test(Baseline (PRE), Week 4 (INT), and Week 8 (POST))
- Peak Power Relative to Body Mass (PPkg)(Baseline (PRE), Week 4 (INT), and Week 8 (POST))
- Mean Velocity at Peak Power (PPmv)(Baseline (PRE), Week 4 (INT), and Week 8 (POST))