Transcranial Doppler guided management of severe traumatic brain injury in trauma intensive care unit
Not Applicable
Completed
- Conditions
- Health Condition 1: S060- ConcussionHealth Condition 2: S062- Diffuse traumatic brain injuryHealth Condition 3: S064- Epidural hemorrhageHealth Condition 4: S063- Focal traumatic brain injuryHealth Condition 5: S068- Other specified intracranial injuriesHealth Condition 6: S061- Traumatic cerebral edemaHealth Condition 7: S066- Traumatic subarachnoid hemorrhageHealth Condition 8: S065- Traumatic subdural hemorrhageHealth Condition 9: S069- Unspecified intracranial injury
- Registration Number
- CTRI/2021/12/038456
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
1.Adult patients 18-65 years of age, with severe TBI (Glasgow Coma Scale 3-8) 25 at the time of admission to Intensive Care Unit
2.Admitted to Trauma Intensive Care Unit (ICU) for mechanical ventilatory support and conservative management.
3.Admitted to Trauma ICU within 48 hours of injury
Exclusion Criteria
1.Pregnant females and pediatric patients
2.Relatives unwilling to give consent for participation in the study
3.Patients admitted to hospital >24 of injury
4.Glasgow Coma Scale (GCS) of 3 with bilateral fixed and dilated pupils
5.Non-survivable injury like decapitation or hemicorporectomy.
•Inability to obtain ultrasound window for performing Transcranial doppler (TCD)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional status and orientation at 3 months following injury, assessed with the use of the Extended Glasgow Outcome Scale [GOS-E](annexure I) and the Disability Rating Scale [DRS](annexure II).Timepoint: 3 months post injury
- Secondary Outcome Measures
Name Time Method . Total ventilator daysTimepoint: end of icu stay;Adverse events/complications, if anyTimepoint: end of icu stay;Brain-specific treatments receivedTimepoint: end of icu stay;Frequency of neurosurgical proceduresTimepoint: end of icu stay;GCS at the end of hospital stayTimepoint: end of hospital stay;Incidence of neurological worseningTimepoint: end of icu stay;Time to hospital dischargeTimepoint: end of hospital stay;Total length of ICU stayTimepoint: end of icu stay