Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function
- Conditions
- Depressive Disorder, Major
Recruitment & Eligibility
- Status
- Not yet recruiting
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria:<br><br> - Must be right-handed<br><br> - Must be illicit drug-free at the time of scanning as appropriate (verified by<br> negative urine drug screen)<br><br> - Must be healthy (without medical, neurological, psychiatric illness)<br><br> - Must be psychotropic medication free (= 14 days)<br><br>Exclusion Criteria:<br><br> - Must not be a smoker<br><br> - Females must not be pregnant or nursing<br><br> - Must not suffer from claustrophobia<br><br> - Must not meet exclusion criteria for MRI scanning (i.e., non-fixed magnetizable<br> objects)<br><br> - Must not have ongoing, chronic, or relapsing/remitting medical, psychiatric,or<br> neurological illness as determined by a combination of history, medical record,<br> and/or examination.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in amygdala activity indicated by functional magnetic resonance imaging (fMRI) scan blood oxygen-level-dependent (BOLD) signal;Changes in brain resting state functional network as indicated by fMRI scan connectivity measures
- Secondary Outcome Measures
Name Time Method Change in performance on Reward Task;Tolerability of LIFUP sonication as assessed number of adverse events