Transcranial ultrasonic stimulation of the primary motor cortex

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

- Between 18-40 years of age
- Right handed
- The ability and agreement to provide informed consent, and the ability to
fulfil the study's requirements

Exclusion Criteria

• Under 18 years of age
• Current pregnancy
• Claustrophobia
• A history or brain surgery or serious head trauma
• A history of or any close relatives (parents, siblings, children) with
epilepsy, convulsion, or seizure
• Predisposition for fainting spells (syncope)
• A cardiac pacemaker or intra-cardiac lines
• An implanted neurostimulator
• Implanted medication infusion device
• Implanted metal devices or large ferromagnetic fragments in the head or
upper body (excluding dental wire), or jewellery/piercing that cannot be
removed • Use of a medical plaster that cannot or may not be taken off (e.g.,
nicotine plaster)
• Cochlear implants
• Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.)
• Diagnosed neurological or psychiatric disorders
• Use of psychoactive (prescription) medication (excluding anti-conception)
• Skin disease at intended stimulation sites
• The consumption of more than four alcoholic units within 24 hours before
participation or any recreational drugs within 48 hours before participation
• All other criteria relevant to non-invasive brain stimulation as reported in
the Donders Standard Operating Procedures for Non-Invasive Brain
Stimulation

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>We will use electromyography (EMG) to measure motor-evoked potentials (MEPs)<br /><br>over the first dorsal interosseous (FDI) elicited by TMS applied over M1. Here,<br /><br>MEP peak-to-peak amplitude is our primary outcome measure. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To determine how well participants are able to discriminate between the<br /><br>ultrasound conditions (sham / active control / verum TUS), including when an<br /><br>auditory mask is played on top of active control and verum TUS, participants<br /><br>will be asked the following questions for 10 additional trials per condition:<br /><br>Do you think you received ultrasonic stimulation (yes/no)? and On which side<br /><br>do you think you were stimulated (left/right)?. Their accuracy/ability to<br /><br>discriminate between conditions is the secondary outcome of this study. </p><br>

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