Transcranial ultrasonic stimulation of the primary motor cortex
- Conditions
- euroscience research (basic science)brain
- Registration Number
- NL-OMON51013
- Lead Sponsor
- Radboud Universiteit Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
- Between 18-40 years of age
- Right handed
- The ability and agreement to provide informed consent, and the ability to
fulfil the study's requirements
* Under 18 years of age
* Current or planned pregnancy
* Claustrophobia
* A history or brain surgery or serious head trauma
* A history of or any close relatives (parents, siblings, children) with
epilepsy,
convulsion, or seizure
* Predisposition for fainting spells (syncope)
* A cardiac pacemaker or intra-cardiac lines
* An implanted neurostimulator
* Implanted medication infusion device
* Implanted metal devices or large ferromagnetic fragments in the head or
upper body (excluding dental wire), or jewellery/piercing that cannot be removed
* Use of a medical plaster that cannot or may not be taken off (e.g., nicotine
plaster)
* Cochlear implants
* Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.)
* Diagnosed neurological or psychiatric disorders
* Use of psychoactive (prescription) medication (excluding anti-conception)
* Skin disease at intended stimulation sites
* The consumption of more than four alcoholic units within 24 hours before
participation or any recreational drugs within 48 hours before
participation
* All other criteria relevant to non-invasive brain stimulation as reported in
the
Donders Standard Operating Procedures for Non-Invasive Brain
Stimulation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We will use electromyography (EMG) to measure motor-evoked potentials (MEPs)<br /><br>over the first dorsal interosseous (FDI) elicited by TMS applied over M1. Here,<br /><br>MEP peak-to-peak amplitude is our primary outcome measure. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Our secondary outcome is establishing the technical feasibility of combining<br /><br>TMS and TUS. Here, we will test the technical operation of the combined TMS-TUS<br /><br>equipment and write a technical report on its operation. </p><br>