Transcranial ultrasonic stimulation of the human amygdala during fear learning

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 67

Inclusion Criteria

- Healthy participants between 18-40 years of age;
- The ability and agreement to provide informed consent, and the ability to
fulfil the study's requirements.

Exclusion Criteria

• Under 18 years of age
• Current or planned pregnancy
• Claustrophobia
• A history or brain surgery or serious head trauma
• A history of or any close relatives (parents, siblings, children) with
epilepsy, convulsion, or seizure
• Predisposition for fainting spells (syncope)
• A cardiac pacemaker or intra-cardiac lines
• An implanted neurostimulator
• Implanted medication infusion device
• Implanted metal devices or large ferromagnetic fragments in the head or upper
body (excluding dental wire), or jewellery/piercing that cannot be removed
• Use of a medical plaster that cannot or may not be taken off (e.g., nicotine
plaster)
• Cochlear implants
• Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.)
• Diagnosed neurological or psychiatric disorders
• Use of psychoactive (prescription) medication (excluding anti-conception)
• Skin disease at intended stimulation sites
• The consumption of more than four alcoholic units within 24 hours before
participation or any recreational drugs within 48 hours before participation

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Electrodermal activity (EDA) is used to index differential skin-conductance<br /><br>responses (SCRs) to the conditioned stimuli (CS+ vs. CS-). EDA is measured<br /><br>using Ag/AgCl electrodes placed on the palmar side of the distal phalanges of<br /><br>the ring and little finger of the left hand.<br /><br><br /><br>The main study parameter falls under the blanket approval for standard research<br /><br>(CMO2014/288, version 3; titled: Imaging Human Cognition).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Heart rate (HR) is used to index differential heart rate responses (HRRs) to<br /><br>the conditioned stimuli (CS+ vs. CS-). HR is measured using electrocardiography<br /><br>(ECG), using lead electrodes attached to the skin surface.<br /><br>- Pupil diameter (PD) is used to index differential pupil dilation responses<br /><br>(PDRs) to the conditioned stimuli (CS+ vs. CS-). PD is recorded by video-based<br /><br>eye-tracking.<br /><br><br /><br>The secondary study parameters fall under the blanket approval for standard<br /><br>research (CMO2014/288, version 3; titled: Imaging Human Cognition).</p><br>