Sildenafil Citrate versus Nifedipine in Women with Recurrent Miscarriages: A Pilot Study

Not Applicable

Recruiting

• Conditions: Pregnancy and Childbirth; Fertility-female; recurrent abortion

• Registration Number: PACTR201710002662398
• Lead Sponsor: Menoufia university hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-03
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Unexplained recurrent miscarriages of three times or more fathered by
the same husband (proved by laboratory documents).
Having no living children.

range (18 ¿ 35) years.
4. Having had regular menstrual cycles in the three months preceding
enrollment.
5. Using neither hormonal contraception nor an intrauterine device.

Exclusion Criteria

Women having anatomical uterine abnormalities such as septate
uterus, 3rd degree RVF or pathological uterine abnormalities such as
myoma or endometrioma on transvaginal ultrasonography.
2. Systemic diseases that may affect hemodynamic indices.
3. A history of oophorectomy or tubal ligation.
4. The presence of side effects or contraindications to both nifedipine and
sildenafil citrate.
5. The occurrence of pregnancy during the first study cycle.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
uterine artery blood flow changes and endometrial thickness following the intake of medications.

Secondary Outcome Measures

Name	Time	Method
medication side effects.