The effect of full-mouth tooth extraction on the oral microflora

Completed

Conditions: gum disease
periodontitis
10004018

Registration Number: NL-OMON37518

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

1) The patient is * 18 years of age;
2) The patient has a hopeless residual dentition of at least 4 teeth for which extraction of all teeth is the only remaining treatment modality.
3) The patient is diagnosed with mild or severe periodontitis (2 approximal sites with at least 2 mm of clinical attachment loss or probing pocket depth of at least 5 mm).
4) The patient is capable of understanding and giving informed consent.

Exclusion Criteria

1) Medical and general contraindications for the surgical procedures;
2) A history of local radiotherapy to the head and neck region;
3) Chemotherapy in the previous 6 months;
4) Systemic or local use of antibiotics in the oral cavity during the last 3 months;
5) Use of anti-septic / antimicrobial therapies (including mouthrinses) in the oral cavity during the last 4 weeks;
6) Patients with dental implants remaining in the oral cavity after full-mouth tooth extraction.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the detection frequency of the periodontal<br /><br>pathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis<br /><br>using both culturing and PCR techniques measure prior to full-mouth tooth<br /><br>extraction and at 2 moments after full-mouth tooth extraction (after 4 weeks<br /><br>and 3 months).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Quantitative analysis of Aggregatibacter actinomycetemcomitans and<br /><br>Porphyromonas gingivalis (culturing and PCR)<br /><br>- Detection frequency of the periodontal pathogens Prevotella intermedia,<br /><br>Tannerella forsythia, Fusobacterium nucleatum, Parvimonas micra and<br /><br>Campylobacter rectus using culturing.<br /><br>- Total bacterial load (culturing)</p><br>