Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients

Completed

• Conditions: Cachexia

• Registration Number: NCT01015274
• Lead Sponsor: The University of Texas Medical Branch, Galveston

Brief Summary

The long-term objective of this research is to develop a non-invasive approach for early assessment of which patients are at high risk for future development of skeletal muscle atrophy. The investigators hypothesize that the rate constant for the terminal portion of the isotope decay curve following ingestion of a single oral dose of deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and that this rate constant can be measured non-invasively from timed spot urine samples.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10
• Study First Submitted: 2009-11-16
• Study First Submitted QC: 2009-11-17
• Study First Posted: 2009-11-18
• Status Verified: 2011-07
• Last Update Submitted: 2018-07-09
• Last Update Posted: 2018-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Male
• 30-75 years old
• Body Mass Index (BMI) <27 kg/m2

Exclusion Criteria

• Uncontrolled hypertension
• Glomerular filtration rate less than 60 mL/min/1.73 m2
• History of recurrent gastrointestinal bleeding
• Unable or unwilling to provide informed consent
• Ongoing anti-coagulant therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

University of Texas Medical Branch; 🇺🇸 Galveston, Texas, United States