Comparative study of clinical effect of sevoflurane vs desflurane on cognitive brain function in patients undergoing surgery with general anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- changes in cognitive function outcome after using sevoflurane or desflurane in general anaesthesia
研究概览
简要总结
the study is a randomised control study done to compare the outcome of sevoflurane and desflurane on cognitive brain function in the postoperative period. To evaluate the incidence and risk factors of delirium and to evaluate hemodynamical changes during intraoperative period. The study group will comprise a two group of 49 each. Preoperative assessment of MMSE score will be done of the patient. The MMSE score assessment will be done in the immediate postoperative period and after 24 hours of the postoperative period.THe data willl be collected and analysed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients willing to participate in the study.
- •Patients with ASA grade 1and 2 with normal cognitive function.
- •Patients undergoing surgery with General Anaesthesia.
排除标准
- •Patients not willing for the study.
- •Patients with abnormal hepatic,neurological,pulmonary,psychiatry,cardiovascular function.
- •Patients who had already participated in another clinical trial.
- •Emergency cases.
结局指标
主要结局
changes in cognitive function outcome after using sevoflurane or desflurane in general anaesthesia
时间窗: assessment of cognitive function immediate postop and 24 hours postoperative
次要结局
- to evaluate the incidence & risk factors of delirium & to evaluate the hemodynamic changes in the intraoperative period(delirium after extubation immediately ,after 6 hours & 24 hours respectively.)
研究者
G R Sukanya
Grant Medical College and JJ Hospital