Influence of Periodontitis and Coronary Heart Disease on Galectin-3
- Conditions
- Periodontal Diseases
- Registration Number
- NCT04564950
- Lead Sponsor
- University of Messina
- Brief Summary
The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis. Furthermore, the objective was to determine if the periodontitis influenced serum and salivary Galectin-3 levels
- Detailed Description
Healthy controls (n=38), patients with CHD (n=39), periodontitis (n=40), and a combination of periodontitis + CHD (n=38) were enrolled in the present study. The analyzed sample undergo a demographical, clinical and periodontal evaluation and serological analyses including Endothelin-1 (ET-1) and for serum and salivary Galectin-3 levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 155
-
Presence of at least 16 teeth
-
CP with a minimum of 40% of sites with a clinical attachment level (CAL)
≥2mm and probing depth (PD) ≥4mm;
-
Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
-
Presence of ≥40% sites with bleeding on probing (BOP)
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of Clinical Attachment Level (mm) 1-year Measurment of changes in Clinical Attachment Level
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Messina
🇮🇹Messina, Italy
University of Messina🇮🇹Messina, Italy