Magnetic resonance imaging of the healthy pediatric knee and wrist: defining normal values for synovial thickness.

Completed

• Conditions: Childhood arthritis; Juvenile Idiopathic Arthritis; 10003816; 10023213

• Registration Number: NL-OMON39297
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Scheduled to undergo an MR Enterography with intravenous gadolinium contrast
- Written informed patients (when >12 years of age) and parental consent.

Exclusion Criteria

- Age < 8 and * 18 years.
- Congenital or genetic joint abnormalities (e.g. Down syndrome, Turner*s syndrome).
- A history of trauma of the wrist and the knee.
- Any arthritic diseases (e.g. JIA, systemic lupus erythematosus, mixed connective tissue disease).
- Other chronic conditions affecting the skeleton (e.g. growth hormone deficiency, hypothyroidism).
- Current use of immunosuppressive medication (e.g. prednisone, azathioprine).
- Signs of any joint inflammation during physical examination.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Normal values for synovial thickness on 6 locations in the healthy knee or<br /><br>wrist of children on MRI after IV contrast.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation of normal values for synovial thickness on MRI between two<br /><br>age-dependent subgroups (8-12 and 13-18 years) on MRI after IV contrast </p><br>