Comparison of Sugammadex and Neostigmine to change the effect of Rocuronium in adult patients undergoing neurosurgery
Phase 4
- Conditions
- Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere
- Registration Number
- CTRI/2024/03/064138
- Lead Sponsor
- AIIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA grade 1&2 patients, aged 18-65 yrs scheduled for elective neurosurgery and planned for extubation immediately following surgery
will be included for the study.
Exclusion Criteria
The following patients will be excluded from the study:
1.Refusal of consent.
2.Patients with Glasgow Coma Scale (GCS) <15 preoperatively or postoperatively.
3.Patients having psychotic disorders
4.Pregnant patients
5.Patients intended for postoperative mechanical ventilation or not extubated after surgery
6.Known or suspected allergy to study drugs
7.Patients with uncontrolled hypertension, uncontrolled D.M or heart disease
8.Patient with history of late recovery from anaesthesia previously
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method time taken from the point of administration of reversal to extubationTimepoint: After surgery,the time point of administration of reversal is taken as 0 minutes.From 0 minutes till extubation the time duration will be noted.
- Secondary Outcome Measures
Name Time Method Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure (MAP), heart rate (HR), oxygen saturation(SpO2), temperature, end tidal carbon dioxide (EtCO2), bispectral index(BIS), TOF count and TOF ratio and PTCTimepoint: baseline, induction, intubation, 10 minutes after intubation, incision, closure, stopping of fentanyl, rocuronium, stopping of propofol/inhalational, during reversal administration, at extubation, 1 min after, 2 min after, 5 minutes after and 10 minutes after extubation