Evaluation of fMRI-SAM in the Early Detection of Alzheimer's Disease.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- Comparing fMRI data between 3 groups of subjects: MCI, Alzheimer's disease and normal subjects
研究概览
简要总结
The aim of the protocol is to study the resting brain activation profile of 3 groups of people, using a new fMRI procedure, called fMRI-SAM. fMRI-SAM will be applied to 25 Alzheimer's disease (AD) patients, 25 patients suffering from amnestic - mild cognitive impairment (MCI) - a clinical picture which may be a prodromal form of AD - and 60 healthy controls. The first analysis of the data will search differences of brain activation profiles between the 3 groups. In the second step, the investigators will study the predictive value of fMRI-SAM to detect MCI patients who will later convert to AD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Alzheimer's disease of mild to moderate severity (25 patients)
- •Amnestic MCI patients (25 patients)
- •55-75 year-old patients
排除标准
- •Any other cause of dementia for AD patients
- •Any stroke
- •Any disease with a negative vital prognosis
研究组 & 干预措施
ALZHEIMER DISEASE
干预措施: fMRI to detect MCI patients who will convert to Alzheimer's disease (Procedure)
MOLD COGNITIVE IMPAIRMENT
干预措施: fMRI to detect MCI patients who will convert to Alzheimer's disease (Procedure)
CONTROLS
干预措施: fMRI to detect MCI patients who will convert to Alzheimer's disease (Procedure)
结局指标
主要结局
Comparing fMRI data between 3 groups of subjects: MCI, Alzheimer's disease and normal subjects
时间窗: 1, 5 years
次要结局
- Follow-up of MCI patients at 6, 12 and 18 months to detect a conversion to Alzheimer's disease(Prediction of Alzheimer's disease on fMRI data)