A single dose intra-articular hyaluronic acid injection in patellofemoral osteoarthritis: a randomized, double-blinded trial
- Conditions
- Patellofemoral ArthritisPatellofemoral arthritisChondromalacia patellaAnterior knee painHyaluronic acidIntra-articular injection
- Registration Number
- TCTR20210224001
- Lead Sponsor
- Queen Savang Vaddhana Memorial Hospital
- Brief Summary
Hyaluronic acid was superior to saline in improving knee pain and function in the immediate pain improvement from day 1 post injection and lasted up to 2 weeks in Patellofemoral arthritis patients. However, no differences were observed in 1 to 6 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 70
1. Diagnosis of Patellofemoral osteoarthritis with anterior knee or retropatellar pain that is exacerbated by knee-bending activity including joint-loading activities, going up the stairs, or standing up from sitting position
2. Age 20-60 years
3. Pain score according to Visual Analogue Scale (VAS) more than equal to 3
4. a trial of conservative treatment for 3 months with no significant improvement
5. Radiological diagnosis of Iwano Classification grade 1-4
1. Osteoarthritis of tibiofemoral joint according to Kellegren and Lawrence Classification of at least grade 3
2. History of allergic reaction of any medication in this study
3. History of prior injury to the knee
4. Infection at the knee
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain 2, 4, 8, 24 week VAS score
- Secondary Outcome Measures
Name Time Method Functional score 2, 4, 8, 24 week WOMAC Score,Range of motion 2, 4, 8, 24 week Knee flexion and Extension in degrees,Adverse reaction 2, 4, 8, 24 week Clinical Observation of skin reaction and infection