Potential therapeutic effect induced by melatonin supplementation and combined physical activity on postural stability and biological responses in obese patients

Phase 3

Completed

• Conditions: Nutritional, Metabolic, Endocrine

• Registration Number: PACTR202006677216503
• Lead Sponsor: Research Laboratory molecular bases of human pathology LR19ES13 Faculty of medicine of Sfax

Brief Summary

Inflammatory responses, muscle damage and biomarkers of oxidative stress have been assessed before and after HIIE. MLT ingestion attenuated the increase of inflammation in Leucocytes (-6.63%; p<0.01), Neutrophils (-8.14%; p<0.01), and C-reactive protein (-9.1%; p<0.001)), hepatic and muscle damage in ASAT (-3.52%; p<0.001), ALAT (-3.47%; p<0.001) and Creatine kinase (-3.94%; p<0.05) and the lipid and protein peroxidation (malondialdehyde (-11.01%; p<0.05), AOPP (-16.86%; p<0.001)). Additionally, the enzymatic antioxidant biomarkers were enhanced (Thiol (+23.81%; p<0.01), Catalase (+20.17%; p<0.01)) in the MLT session compared to the placebo session after HIIE.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-04
• Results First Posted: 2020-06-08
• Last Update Posted: 2023-05-29

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Age 20-50 years
- BMI> 30 kg / m2
- Circumference of height> 94 cm (man)
- Circumference of the waist> 80 cm (woman)
- No use of medication
- No regular exercise for at least 6 months

Exclusion Criteria

- Against indication to the effort
- Antecedent injury
- Cardiorespiratory disease
- Diabetes type 2
- Smoker

Study & Design

• Study Type: Interventional
• Study Design: Not specified