Pilot Study on the Tolerability of Dietary Dried Plum

Not Applicable

Completed

• Conditions: Healthy; Elderly
• Interventions: Dietary Supplement: dried plum powder

• Registration Number: NCT01035372
• Lead Sponsor: University of California, San Francisco

Brief Summary

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2009-12-16
• Study First Submitted QC: 2009-12-16
• Study First Posted: 2009-12-18
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-26
• Last Update Posted: 2020-03-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Age between 50 yrs and 75 yrs
• Nonsmokers
• Normal renal and hepatic function

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Exclusion Criteria

• Subjects who must follow a specific diet
• Subjects on any daily medications that affect bone health
• Subjects too heavy for the DEXA machine (weight limit 300 lbs)
• Subjects whose BMD by DEXA indicates osteoporosis
• Subjects unwilling to follow the diet specified
• Pregnant women
• Subjects who are unable to understand the consent form.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
dried plum	dried plum powder	subjects will have 25% by weight (\~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder

Primary Outcome Measures

Name	Time	Method
urinary calcium excretion	one month

Secondary Outcome Measures

Name	Time	Method
ability to tolerate the diet	one month

Trial Locations

Locations (1)

University of California San Francisco; 🇺🇸 San Francisco, California, United States