Pilot Study on the Tolerability of Dietary Dried Plum
- Conditions
- HealthyElderly
- Registration Number
- NCT01035372
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
- Age between 50 yrs and 75 yrs
- Nonsmokers
- Normal renal and hepatic function
- Subjects who must follow a specific diet
- Subjects on any daily medications that affect bone health
- Subjects too heavy for the DEXA machine (weight limit 300 lbs)
- Subjects whose BMD by DEXA indicates osteoporosis
- Subjects unwilling to follow the diet specified
- Pregnant women
- Subjects who are unable to understand the consent form.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method urinary calcium excretion one month
- Secondary Outcome Measures
Name Time Method ability to tolerate the diet one month
Trial Locations
- Locations (1)
University of California San Francisco
🇺🇸San Francisco, California, United States
University of California San Francisco🇺🇸San Francisco, California, United States