NL-OMON46302已完成不适用
Platelet reactivity, inflammation and endothelial dysfunction during and after exacerbation in chronic obstructive pulmonary disease (COPD) patients - IMPROVE study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* Acute exacerbation of COPD, defined as an as an acute worsening of respiratory symptoms that results in additional therapy (COPD Gold 2018)
- •* >40 years oud
- •* Moderate to severe (>Gold 2) airflow limitation detected by spirometry (FEV1/FVC ratio < 70%, FEV1 < 80%) and clinical diagnosis of COPD confirmed by a pulmonologist.
- •* Current or former smoker, with *10 pack years of smoking
排除标准
- •* Suspected or proven alternative diagnosis for the acute deterioration in symptoms such as pneumonia, pulmonary embolism or heart failure
- •* Use of anti-coagulants, aspirin or other platelet function inhibitors
- •* Use of statins or ACE inhibitors
- •* Concomitant diagnosis of asthma or other respiratory disease
- •* Diagnosis of hepatic and/or renal failure
- •* Chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel diseases, systemic lupus erythematous (SLE), diabetes mellitus (DM)
- •* Malignancies (excluding basal cell carcinoma of the skin)
研究者
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