NL-OMON46302CompletedNot Applicable
Platelet reactivity, inflammation and endothelial dysfunction during and after exacerbation in chronic obstructive pulmonary disease (COPD) patients - IMPROVE study
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Gelre Ziekenhuizen
- Enrollment
- 76
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •* Acute exacerbation of COPD, defined as an as an acute worsening of respiratory symptoms that results in additional therapy (COPD Gold 2018)
- •* >40 years oud
- •* Moderate to severe (>Gold 2) airflow limitation detected by spirometry (FEV1/FVC ratio < 70%, FEV1 < 80%) and clinical diagnosis of COPD confirmed by a pulmonologist.
- •* Current or former smoker, with *10 pack years of smoking
Exclusion Criteria
- •* Suspected or proven alternative diagnosis for the acute deterioration in symptoms such as pneumonia, pulmonary embolism or heart failure
- •* Use of anti-coagulants, aspirin or other platelet function inhibitors
- •* Use of statins or ACE inhibitors
- •* Concomitant diagnosis of asthma or other respiratory disease
- •* Diagnosis of hepatic and/or renal failure
- •* Chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel diseases, systemic lupus erythematous (SLE), diabetes mellitus (DM)
- •* Malignancies (excluding basal cell carcinoma of the skin)
Investigators
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