NL-OMON46302
Completed
Not Applicable
Platelet reactivity, inflammation and endothelial dysfunction during and after exacerbation in chronic obstructive pulmonary disease (COPD) patients - IMPROVE study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Gelre Ziekenhuizen
- Enrollment
- 76
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\* Acute exacerbation of COPD, defined as an as an acute worsening of respiratory symptoms that results in additional therapy (COPD Gold 2018\)
- •\* \>40 years oud
- •\* Moderate to severe (\>Gold 2\) airflow limitation detected by spirometry (FEV1/FVC ratio \< 70%, FEV1 \< 80%) and clinical diagnosis of COPD confirmed by a pulmonologist.
- •\* Current or former smoker, with \*10 pack years of smoking
Exclusion Criteria
- •\* Suspected or proven alternative diagnosis for the acute deterioration in symptoms such as pneumonia, pulmonary embolism or heart failure
- •\* Use of anti\-coagulants, aspirin or other platelet function inhibitors
- •\* Use of statins or ACE inhibitors
- •\* Concomitant diagnosis of asthma or other respiratory disease
- •\* Diagnosis of hepatic and/or renal failure
- •\* Chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel diseases, systemic lupus erythematous (SLE), diabetes mellitus (DM)
- •\* Malignancies (excluding basal cell carcinoma of the skin)
Outcomes
Primary Outcomes
Not specified
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