Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN22305120
ISRCTN22305120
Completed
Not Applicable

The role of platelet activation and inflammation in the adverse Cardiovascular outcomes of patients undergoing surgery for Critical Limb ISchaemia: a double-blind randomised controlled trial of clopidogrel

othian Health Board (LHB) (UK)0 sites100 target enrollmentJune 23, 2008
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsCritical limb ischaemiaCirculatory SystemArterial embolism and thrombosis

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Critical limb ischaemia
Sponsor
othian Health Board (LHB) (UK)
Enrollment
100
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
June 23, 2008
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
othian Health Board (LHB) (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Patients aged greater than 45 years, either sex
  • •2\. Critical limb ischaemia, defined as the presence of rest pain or skin breakdown, and an ankle\-brachial pressure index less than 0\.2
  • •3\. Scheduled for infra\-inguinal bypass, endarterectomy or amputation under general anaesthesia

Exclusion Criteria

  • •1\. Women of child bearing potential
  • •2\. Non\-atherosclerotic vascular disease
  • •3\. Sudden acute limb ischaemia requiring emergency surgery
  • •4\. Supra\-inguinal or aortic surgery
  • •5\. History of acute coronary syndrome within three months
  • •6\. History of peptic ulcer disease
  • •7\. Previous or current intracranial haemorrhage
  • •8\. Bleeding diathesis
  • •9\. Uncontrolled hypertension or thrombocytopenia
  • •10\. Planned epidural or spinal anaesthesia

Outcomes

Primary Outcomes

Not specified

Similar Trials

Active, not recruiting
Phase 1
Role of Inflammation and Platelet Activation in the adverse Cardiovascular Outcomes of Patients with Critical Limb Ischaemia - a double-blind randomised trial of Clopidogrel. - Platelet activation and Clopidogrel in Critical Limb IschaemiaPeripheral Vascular Disease (Critical Limb Ischaemia)
EUCTR2005-000960-25-GBothian NHS trust200
Completed
Not Applicable
The role of inflammatory mediators (platelet activity,the number and origin of micro particles and levels of mitochondrial DNA) in patient with acute renal transplant rejection.acute renal transplant injuryrenal inflammation1000381610029149
NL-OMON41402Academisch Medisch Centrum65
Completed
Not Applicable
Platelet activation and responsiveness in patients with acute exacerbations of chronic obstructive pulmonary disease (AE-COPD)
NL-OMON45449Academisch Medisch Centrum30
Completed
Not Applicable
Platelet reactivity, inflammation and endothelial dysfunction during and after exacerbation in chronic obstructive pulmonary disease (COPD) patients
NL-OMON46302Gelre Ziekenhuizen76
Completed
Not Applicable
Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock.Septic Shock
NCT04080453University Hospital, Bordeaux202