Decrement of the Dual-task Performance in Individuals With Young-onset Parkinson's Disease and the Training Effects
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- Dual-task walking performance
研究概览
简要总结
This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values of executive function and dual-task performance after training. Besides, investigate cortical activation after training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed as PD and Hoehn and Yahr stage between 1~3
- •Age between 20 to 80
- •Able to walk 10 m independently without an assistive device
- •A score of greater than or equal to 24 on the mini-mental state examination (MMSE)
- •In stable medical condition allowing participation in the testing protocol and intervention
排除标准
- •Any comorbidity or disability other than PD that would preclude gait training
- •Any uncontrolled health condition for which exercise was contraindicated
- •Any neurological or orthopedic disease that might interfere with the study
- •Server freezing of gait, FOG questionnaire > 15
研究组 & 干预措施
Game based dual-task training group
Participants in dual-task training group will execute game based dual-task training with treadmill, 3 times per week for 8 weeks
干预措施: Game based dual-task training (Other)
Treadmill training group
Participants in treadmill training group will do treadmill training, 3 times per week for 8 weeks
干预措施: Treadmill training (Other)
结局指标
主要结局
Dual-task walking performance
时间窗: Change from baseline at 8 weeks
To evaluate gait parameters while doing dual-task walking
次要结局
- Single walking performance(Change from baseline at 8 weeks)
- Verbal fluency test-Chinese version(Change from baseline at 8 weeks)
- Functional near-infrared spectroscopy(Change from baseline at 8 weeks)
- Parkinson's Disease Questionnaire 39(Change from baseline at 8 weeks)
- Timed up and go test(Change from baseline at 8 weeks)
- Trail-making test(Change from baseline at 8 weeks)
- Dual-task costs(Change from baseline at 8 weeks)
- Stroop color and word test-Chinese version(Change from baseline at 8 weeks)
- Frontal lobe battery test-Chinese version(Change from baseline at 8 weeks)
- Digit span test(Change from baseline at 8 weeks)
研究者
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University