Association of Hb F Level With Clinical Severity of Beta Thalassemia

Recruiting

• Conditions: Beta Thalassemia
• Interventions: Diagnostic Test: Hematological Phenotype Analysis

• Registration Number: NCT04917978
• Lead Sponsor: Nanfang Hospital, Southern Medical University

Brief Summary

The production of Hb F after birth is an important factor in modifying the clinical severity of beta thalassemia because an increased gamma-globin level will bind the additional a-globin and form Hb F. The objective of this project is to evaluate the association of Hb F level with phenotypic diversity of patients with beta thalassemia.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-01
• Status Verified: 2021-05
• Study First Submitted: 2021-06-03
• Study First Submitted QC: 2021-06-07
• Study First Posted: 2021-06-08
• Last Update Submitted: 2021-06-08
• Last Update Posted: 2021-06-11
• Primary Completion: 2024-12-30
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Diagnosed with beta-thalassemia

Exclusion Criteria

• Iron Deficiency Anemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
beta thalassemia patients	Hematological Phenotype Analysis	-

Primary Outcome Measures

Name	Time	Method
Hb F level and severity of anemia	3 years	Observational study that analyzed association of Hb F level and anemia severity in patients

Trial Locations

Locations (1)

Southern Medical University; 🇨🇳 Guangzhou, Guangdong, China