Physical Activity, Air Pollution, and High Blood Pressure
- Conditions
- Essential Hypertension
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT05092672
- Lead Sponsor
- University of British Columbia
- Brief Summary
The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. Participants will be exposed to 2 conditions: a low TRAP environment and a high TRAP environment. Each exposure will consist of 30 min of moderate-intensity exercise. Cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. A minimum washout period of 1 week will be used to minimize carryover effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- Age between 40-70 years of age
- Previously diagnosed with elevated blood pressure or hypertension by a physician
- Current or ex-smokers (abstinent for less than one year)
- Lives with an individual who currently smokes cigarettes, e-cigarettes (i.e., vaping), or cannabis
- Hormone replacement therapy use
- Currently on beta-blocker or angiotensin receptor blocker (ARB) therapy
- Currently using over the counter drugs or supplements that may alter cardiovascular measures (as per the principal investigator's discretion)
- Prior diagnosis of any other existing cardiovascular or pulmonary diseases and/or conditions (other than hypertension)
- Musculoskeletal injury or lower limb limitation preventing safe engagement in moderate-intensity exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Low traffic-related air pollution Exercise Participants will exercise in an environment with low levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with high levels of traffic-related air pollution. High traffic-related air pollution first Exercise Participants will exercise in an environment with high levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with low levels of traffic-related air pollution.
- Primary Outcome Measures
Name Time Method Change from Baseline Blood Pressure at 2 Hours Post-Exposure Baseline and 2 hours post-exposure MAP, SBP, and DBP
- Secondary Outcome Measures
Name Time Method 24-Hour Blood Pressure 24 hours post-exposure MAP, SBP, and DBP
Change from Baseline Arterial Stiffness at 2 Hours Post-Exposure Baseline and 2 hours post-exposure Pulse wave velocity and augmentation index
Heart Rate Variability Baseline and up to 24 hours post-exposure Indices of heart rate variability
Change from Baseline FEV1/FVC at 2 Hours Post-Exposure Baseline and 2 hours post-exposure FEV1/FVC ratio measured by spirometry
Change from Baseline Microvascular Responsiveness at 2 Hours Post-Exposure Baseline and 2 hours post-exposure Microvascular responsiveness (measured by near-infrared spectroscopy)
Change from Baseline FEV1 and FVC at 2 Hours Post-Exposure Baseline and 2 hours post-exposure Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) measured by spirometry (in L)
Muscle Oxygen Saturation Continuously throughout the 30 minute exercise bouts (during exposure) Muscle oxygen saturation (measured by near-infrared spectroscopy)
Change from Baseline FEF25-75 and PEFR at 2 Hours Post-Exposure Baseline and 2 hours post-exposure Forced expiratory flow at 25-75% of forced vital capacity (FEF25-75) and peak expiratory flow rate (PEFR) measured by spirometry (in L/s)
Severity of Symptoms Baseline and 2 hours post-exposure Severity of respiratory symptoms (e.g., dyspnea, cough, wheeze, chest tightness) and headache on a 0-5 scale
Trial Locations
- Locations (1)
University of British Columbia
🇨🇦Vancouver, British Columbia, Canada