Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence
- Conditions
- Neovascular Age-related Macular Degeneration
- Interventions
- Procedure: Anti-vascular endothelial growth factor therapy
- Registration Number
- NCT05208931
- Lead Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
- Brief Summary
The study involves the development of an algorithm for predicting anatomical and functional results of therapy with angiogenesis inhibitors in patients with retinal pigment epithelium detachments in neovascular age-related macular degeneration, based on primary optical coherence tomography of the macular zone and clinical data.
- Detailed Description
Patients were divided into 3 groups according to the results of therapy: adhesion of detachment, lack of adherence to detachment, rupture of detachment. For these groups, OCT images of the macular zone with maximum detachment before therapy are selected. These images, along with other clinical parameters, are input to the algorithm. The result is one of the 3 treatment outcomes listed above. The methods that will be used to develop the algorithm include methods for processing and transforming data, deep machine learning, metrics for calculating the accuracy of algorithms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description adhesion Anti-vascular endothelial growth factor therapy the group in which the adhesion of neuroepithelial detachment was observed after Anti-vascular endothelial growth factor therapy no adhesion Anti-vascular endothelial growth factor therapy group in which there was no adherence of neuroepithelial detachment after Anti-vascular endothelial growth factor therapy разрыв Anti-vascular endothelial growth factor therapy group in which neuroepithelial detachment rupture was observed after anti-vascular endothelial growth factor therapy
- Primary Outcome Measures
Name Time Method Prediction algorithm 1.09.2022 Neural network classifier
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The S.N. Fyodorov Eye Microsurgery State Institution
🇷🇺Krasnodar, Russian Federation