High intensity exercise for non-alcoholic steatohepatitis- is it safe, effective, and feasible in practice?

Not Applicable

Completed

• Conditions: non-alcoholic steatohepatitis; Metabolic and Endocrine - Metabolic disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12616000305426
• Lead Sponsor: The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-03-09
• Study Completion: 2020-03-05
• Last Update Posted: 23 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

Men and women who are not currently meeting physical activity guidelines (<150 minutes of moderate or <75 min of vigorous exercise per week), aged 18-70 years, with biopsy-proven NASH.

Exclusion Criteria

Unstable angina; Recent (4 weeks) myocardial infarction; Coronary Artery Disease; Uncompensated heart failure; New York Heart Association (NYHA) Functional Classification II-IV; Severe valvular illness; Pulmonary disease; Uncontrolled hypertension (systolic blood pressure > 200 mmHg and/or diastolic blood pressure >110 mmHg); Renal failure (Chronic Kidney Disease stages III-V); Orthopedic/neurological limitations; Cardiomyopathy; Planned operations during the research period; Physical impairment limiting the ability to exercise; Drug or alcohol abuse; Planning to or participation in another study; Not willing to sign the consent from; Females pregnant or expecting to be pregnant during the study period; Lactating females; Contraindication to exercise testing/training; Medication affecting insulin sensitivity and/or evidence of cirrhosis; Any other reason which would limit their ability to participate in this study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in insulin sensitivity:assessed via the euglycemic hyperinsulinaemic clamp [This will be assessed at baseline and week 12 for the HIIT intervention, and baseline, week 12 and week 24 for the stretch control group who then go on to do HIIT. ];Change in cardiorespiratory fitness (VO2peak, assessed via expired air gas analysis during an exercise stress test)[This will be assessed at baseline and week 12 for the HIIT intervention, and baseline, week 12 and week 24 for the stretch control group who then go on to do HIIT. ]