HSPG Expression in non-alcoholic steato hepatitis And type II Diabetes Mellitus.

Completed

• Conditions: ASH; sugar disease; type 2 diabetes mellitus; 10018424; 10013317

• Registration Number: NL-OMON36347
• Lead Sponsor: Slotervaartziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

• Caucasian males or females
• Age 18 - 60 years old
• Type 2 diabetes mellitus
• Presence of ultrasound confirmed NASH
• Undergoing gastric bypass surgery

Exclusion Criteria

• Active malignancy
• Cholestasis
• History of Hepatitis B/Hepatitis C

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>•HSPGs expression in liver tissue and gutepithelium, measured by qPCR and<br /><br>western blot, in insulin resistant NASH versus non-insulin resistant NASH and<br /><br>controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>•Association between hepatic and gut epithelium HSPGs expression and<br /><br>triglyceride-rich lipoproteins and FFA*s in non fasting peripheral and portal<br /><br>lipid samples versus feces sample.<br /><br>•Association between hepatic HSPGs expression and HOMA index</p><br>