Vitamin D and T-Regulatory Cells in Coronary Artery Disease
- Conditions
- Coronary Artery DiseaseCardiovascular Disease
- Registration Number
- NCT01183962
- Lead Sponsor
- Creighton University
- Brief Summary
The purpose of this study is to evaluate the effect of Vitamin D supplementation on cardiovascular disease and certain cells (T-regulatory cells) in the body that play a role in plaque formation in arteries. This study will determine the levels of Vitamin D and T-regulatory cells in subjects with coronary artery disease and if Vitamin D supplementation will affect future events such as heart attach and stroke.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 50
- between the ages of 30 and 80 years
- have a history of medically treated coronary artery disease
- history of smoking in the past 2 years
- history of diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method increase in T-regulatory Cells 1 year We expect significant improvement in the suppressive capacity, with or without increase in the number, of circulating T-regs after vitamin D supplementation. This increase in T-regs function will correlate with improvement in clinical parameters.
- Secondary Outcome Measures
Name Time Method decrease pro-inflammatory cytokines & sTNFR1 and increase serum IL-10 1 year We also expect that vitamin D supplementation will decrease the levels of pro-inflammatory cytokines and sTNFR1 and increase the level of serum IL-10
Trial Locations
- Locations (1)
The Cardiac Center at Creighton University
🇺🇸Omaha, Nebraska, United States
The Cardiac Center at Creighton University🇺🇸Omaha, Nebraska, United States