Pneumothorax After CT-guided Lung Biopsy: Standard vs Autologous Blood Patching
- Conditions
- Biopsy WoundPneumothorax
- Registration Number
- NCT03804957
- Lead Sponsor
- Humanitas Clinical and Research Center
- Brief Summary
The aim of this prospective, randomized study is to compare the rate of postoperative pneumothorax between standard CT-guided core needle biopsy (CNB) versus CNB followed by autologous blood patch injection (ABPI).
- Detailed Description
Pneumothorax is the most common complication of percutaneous lung biopsies. Reducing this risk is a goal of those who perform these procedures, particularly a reduction in large pneumothoraces requiring intervention (eg, pleural drainage) and hospitalization (Clayton et al. 2016). Recently, autologous blood patch injection (ABPI) inside the biopsy track has been suggested as an effective mean of sealing the punctured lung thus halting air loss and consequently pneumothorax (Graffy et al. 2017).
The aim of this prospective, randomized study is to compare the rate of postoperative pneumothorax between standard CT-guided core needle biopsy (CNB) versus CNB followed by ABPI.
In particular, the main objectives are to compare:
1. incidence of immediate pneumothorax
2. incidence of late pneumothorax (2 hrs)
3. incidence of chest tube placement
4. duration of the procedure
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Early Pneumothorax after biopsy Immediately after lung puncture Early Pneumothorax after biopsy as seen by immediate post-biopsy CT and X-ray
- Secondary Outcome Measures
Name Time Method Late Pneumothorax after biopsy 2-6 hours Delayed Pneumothorax after biopsy as seen by X-ray after 2-6 hours
Trial Locations
- Locations (1)
Humanitas Research Hospital
🇮🇹Rozzano, Lombardia, Italy
Humanitas Research Hospital🇮🇹Rozzano, Lombardia, Italy