Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)
Completed
- Conditions
- Atherosclerosis
- Interventions
- Other: Cross sectional study
- Registration Number
- NCT01150019
- Lead Sponsor
- Korea University
- Brief Summary
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
- Healthy volunteers for visiting routine medical check in our clinic
Exclusion Criteria
- History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
- Diabetes
- Hypertension
- Malignancy
- Severe renal or hepatic disease
- Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Obese Group Cross sectional study - Non Obese Group Cross sectional study -
- Primary Outcome Measures
Name Time Method Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET 12 weeks
- Secondary Outcome Measures
Name Time Method Circulating serum resistin levels 12 weeks Circulating serum adiponectin levels 12 weeks carotid intima-media thickness levels measured using ultrasonography 12 weeks
Trial Locations
- Locations (1)
Hae Yoon Choi
🇰🇷Seoul, Korea, Republic of