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Clinical Trials/NCT01150019
NCT01150019
Completed
Not Applicable

Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Korea University1 site in 1 country120 target enrollmentApril 2010
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ConditionsAtherosclerosis

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Atherosclerosis
Sponsor
Korea University
Enrollment
120
Locations
1
Primary Endpoint
Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET
Status
Completed
Last Updated
15 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Registry
clinicaltrials.gov
Start Date
April 2010
End Date
June 2010
Last Updated
15 years ago
Study Type
Observational
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria

  • •History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • •Hypertension
  • •Malignancy
  • •Severe renal or hepatic disease
  • •Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Outcomes

Primary Outcomes

Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET

Time Frame: 12 weeks

Secondary Outcomes

  • Circulating serum resistin levels(12 weeks)
  • Circulating serum adiponectin levels(12 weeks)
  • carotid intima-media thickness levels measured using ultrasonography(12 weeks)

Study Sites (1)

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