Vascular Inflammation Stratified by Body Size Phenotype

Completed

• Conditions: Obesity; Metabolic Syndrome; Atherosclerosis

• Registration Number: NCT01979068
• Lead Sponsor: Korea University

Brief Summary

* Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque

* Recently, unique subsets of obese individuals, such as metabolically obese but normal weight (MONW) and metabolically healthy obese (MHO), have been getting an attention

* Therefore, the purpose of this study is to examine the relationship of vascular inflammation,measured by FDG-PET, with various body sized phenotypes

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Primary Completion: 2011-03
• Study First Submitted: 2013-10-28
• Status Verified: 2013-11
• Study First Submitted QC: 2013-11-03
• Last Update Submitted: 2013-11-03
• Study First Posted: 2013-11-08
• Last Update Posted: 2013-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria

• history of CVD (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
• stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
• history of inflammatory conditions that affect the study results
• taking medications that might affect inflammatory status, including steroid and non-steroidal anti-inflammatory drug within 6 months
• or malignancy or severe renal or hepatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
max TBR values stratified by the four body size phenotypes	12 weeks

Secondary Outcome Measures

Name	Time	Method
Framingham risk scores according to the four body size phenotypes	12 weeks

Trial Locations

Locations (1)

Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of