Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography

Korea University1 site in 1 country150 target enrollmentDecember 2009

ConditionsAtherosclerosis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Atherosclerosis
Sponsor: Korea University
Enrollment: 150
Locations: 1
Primary Endpoint: Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET
Status: Completed
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.

Registry

clinicaltrials.gov

Start Date

December 2009

End Date

January 2010

Last Updated

16 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Korea University

Eligibility Criteria

Inclusion Criteria

•Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria

•History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
•Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
•Malignancy
•Severe renal or hepatic disease
•Subjects taking medications that might affect inflammation such as NSIAD and statin