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Clinical Trials/NCT01958411
NCT01958411
Completed
Not Applicable

Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Korea University1 site in 1 country340 target enrollmentDecember 2008
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ConditionsAtherosclerosisNon-alcoholic Fatty Liver Disease

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Atherosclerosis
Sponsor
Korea University
Enrollment
340
Locations
1
Primary Endpoint
Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT
Status
Completed
Last Updated
12 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

  • Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.
  • Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT).
  • Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population.
  • Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.
Registry
clinicaltrials.gov
Start Date
December 2008
End Date
March 2011
Last Updated
12 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

K. M. Choi

Professor

Korea University

Eligibility Criteria

Inclusion Criteria

  • •Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria

  • •History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
  • •Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
  • •Malignancy
  • •Severe renal or hepatic disease
  • •Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin

Outcomes

Primary Outcomes

Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT

Time Frame: 12 weeks

Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT

Time Frame: 12 weeks

Secondary Outcomes

  • The relationship of NAFLD with carotid intima media thickness(12 weeks)
  • The relationship of epicardial adipose tissue volume with carotid intima media thickness(12 weeks)

Study Sites (1)

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