The role of small, non-coding RNAs (miRNAs) in the development of aseptic loosening following total hip arthroplasty

Not Applicable

• Conditions: Aseptic loosening following primary total hip replacement; Musculoskeletal Diseases

• Registration Number: ISRCTN25839413
• Lead Sponsor: niversity of Patras

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-03-18
• Last Update Posted: 1 April 2024
• Study Completion: 2024-10-12

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. Aged >40 years old
2. Patients undergoing primary total hip arthroplasty (THA) due to degenerative hip osteoarthritis (Group A)
3. Patients who underwent primary THA, without clinical and radiological evidence of periprosthetic osteolysis and aseptic loosening (Group B)
4. Patients undergoing revision surgery after primary THA, with clinical and radiological evidence of periprosthetic osteolysis and aseptic loosening (Group C)

Exclusion Criteria

1. Revision total hip arthroplasty (THA) surgery
2. Bilateral THA or hemiarthroplasty on the contra-lateral hip
3. Pre-existing other joint replacement
4. Inflammatory markers and intraoperative cultures indicating potential septic loosening
5. Cancer or immunodeficiency, patients receiving chemotherapy or immunosuppressive medication
6. Autoimmune diseases
7. Severe cognitive defects or psychiatric disorders
8. Inability to provide written informed consent to the study

Study & Design

• Study Type: Observational
• Study Design: Not specified