Improving the Therapeutic Ratio by Using Proton Beam Radiation Therapy for Patients With Stage IA-IIIBX (Bulky/Non-bulky) Hodgkin Lymphoma Involving the Mediastinum Following Standard Chemotherapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hodgkin Lymphoma
- Sponsor
- University of Florida
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.
Detailed Description
3 treatment plans will be created to deliver between a total of 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV). 1. Proton Plan 2. Conventional Plan 3. Intensity Modulated Radiotherapy (IMRT) Plan The patient will then receive the radiation modality with the lowest percentage of the body receiving 4 Gy (V4Gy/CGE)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Confirmed "classic" Hodgkin lymphoma.
- •Completed chemotherapy.
Exclusion Criteria
- •Prior radiotherapy.
- •Prior or concurrent cancer other than non-melanomatous skin cancer.
Outcomes
Primary Outcomes
Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.
Time Frame: Immediately proceeding completion of each of the three treatment plans
Secondary Outcomes
- Percentage of Participants Who Survived(4 years after beginning of radiation therapy)
- Percentage of Participants Who Did Not Have Disease Progression(4 years after beginning of radiation therapy)