Proton Therapy for Unresectable Cancer (CA) of Pancreas
Not Applicable
Completed
- Conditions
- Pancreatic Cancer
- Registration Number
- NCT00685763
- Lead Sponsor
- University of Florida
- Brief Summary
The purpose of this study is to find out what effects, good and/or bad, proton radiation and chemotherapy has on you and your pancreatic cancer.
- Detailed Description
Chemotherapy:Capecitabine on radiation days
Proton radiation over 7 weeks
Consolidation Chemotherapy:Gemcitabine
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
Pathologically confirmed adenocarcinoma of the pancreas.
Patients must be medically inoperable or have unresectable disease
Exclusion Criteria
- Evidence of distant metastasis; evidence of metastatic disease in the major viscera (organs), peritoneal seeding and/or ascites.
- Previous irradiation to the abdomen that would compromise the ability to deliver the prescribed treatment.
- Prior surgical resection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Cumulative Incidence of grade3+ Bowel Perforation, Grade 3+ Bleeding (Ocurring Withing 1 Years) and grade4+ Nonhematologic Acute Adverse Events (Limited to Within 90 Days of Treatment Start) 1 year following the completion of radiation therapy
- Secondary Outcome Measures
Name Time Method Collect and Analyze Tumor Control Measures 1 year following the completion of radiation therapy
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie proton therapy's efficacy in unresectable pancreatic cancer?
How does proton beam therapy compare to conventional photon therapy in treating pancreatic carcinoma?
Which biomarkers correlate with response to proton radiation and capecitabine in pancreatic cancer patients?
What are the common adverse events associated with proton therapy and gemcitabine-based chemotherapy regimens?
Are there combination approaches involving proton therapy and targeted agents for pancreatic cancer?
Trial Locations
- Locations (1)
University of Florida Proton Therapy Institute
🇺🇸Jacksonville, Florida, United States
University of Florida Proton Therapy Institute🇺🇸Jacksonville, Florida, United States