Effects of roflumilast on memory, attention and response inhibition tested using computer tasks and elctrical brain activity
- Conditions
- onethis proof-of-principle study will examine the cognition enhancing effects of roflumilast in healthy subjectsTherapeutic area: Psychiatry and Psychology [F] - Psychological processes [F02]
- Registration Number
- EUCTR2011-002070-23-NL
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 22
•18 to 35 years of age
•Healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected),
•Body mass index between 18.5 and 30
•Willingness to sign an informed consent.
•Positive evaluation on the memory screening
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 22
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Volunteers who suffer from, or have a history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric illness, will be excluded. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of depressive disorder with or without suicidal risk will be excluded as well. Other exclusion criteria are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of chronic medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, smoking, orthostatic hypotension, lactose intolerance, and any sensory or motor deficits which could reasonably be expected to affect test performance.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method