Effects of roflumilast on cognition in healthy adults: a behaviour-EEG study
- Conditions
- Geheugenproblemennvt
- Registration Number
- NL-OMON36123
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Male or female, 18 to 35 years of age, healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected), body mass index between 18.5 and 30, willingness to sign an informed consent, positive evaluation on the medical and memory screening
Volunteers who suffer from, or have a history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric illness, will be excluded. Other exclusion criteria are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of chronic medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, smoking, ortostatic hypotension, lactose intolerance, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of depressive disorder with or without suicidal risk will be excluded as well.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint is the behavioural score on the memory tests; the verbal<br /><br>learning task (VLT) and the object relocation task (ORT). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Other important measures are the Stroop task and continuous performance taak<br /><br>(CPT-AX). In addition, the event-related potentials during those tasks will be<br /><br>analysed. Moreover, the ratio (S2/S1) of the P50 is a measure of sensory<br /><br>gating.</p><br>