Genetic Susceptibility to Lung Cancer in Never Smokers

Memorial Sloan Kettering Cancer Center1 site in 1 country238 target enrollmentJune 2005

ConditionsLung Cancer

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Lung Cancer
Sponsor: Memorial Sloan Kettering Cancer Center
Enrollment: 238
Locations: 1
Primary Endpoint: To evaluate germline genetic variants and their association with lung cancer in never smokers.
Status: Active, not recruiting
Last Updated: 10 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people who have never smoked and yet have been diagnosed with lung cancer to never smokers who have not developed lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.

Registry

clinicaltrials.gov

Start Date

June 2005

End Date

June 2026

Last Updated

10 months ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Memorial Sloan Kettering Cancer Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Cases will be eligible for inclusion if:
•They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
•They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected)
•They speak and read English
•They understand and agree to sign informed consent, and
•They agree to give us a blood sample, and
•They agree to complete the study questionnaire, and
•They agree to have their pathology information reviewed by study personnel.
•Controls will be eligible for inclusion if:
•They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and

Exclusion Criteria

•Subjects who do not meet the inclusion criteria for either the case or control groups will not be eligible for this study.
•All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).