NCT00597636进行中（未招募）不适用
Genetic Susceptibility to Lung Cancer in Never Smokers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 238
- 试验地点
- 1
- 主要终点
- To evaluate germline genetic variants and their association with lung cancer in never smokers.
研究概览
简要总结
The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people who have never smoked and yet have been diagnosed with lung cancer to never smokers who have not developed lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cases will be eligible for inclusion if:
- •They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
- •They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected)
- •They speak and read English
- •They understand and agree to sign informed consent, and
- •They agree to give us a blood sample, and
- •They agree to complete the study questionnaire, and
- •They agree to have their pathology information reviewed by study personnel.
- •Controls will be eligible for inclusion if:
- •They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
- •They speak and read English
- •They understand and agree to sign informed consent, and
- •They agree to give us a blood sample, and
- •They agree to complete the study questionnaire.
排除标准
- •Subjects who do not meet the inclusion criteria for either the case or control groups will not be eligible for this study.
- •All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).
结局指标
主要结局
To evaluate germline genetic variants and their association with lung cancer in never smokers.
时间窗: conclusion of study
次要结局
- To evaluate whether overall DNA damage/repair capacity is associated with lung cancer in never smokers.(conclusion of study)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
DNA Repair and Genetic Susceptibility to Lung CancerSingle Primary Lung CancerSecond Primary Lung CancerLung CancerNCT00611598Memorial Sloan Kettering Cancer Center218
招募中
不适用
Detection of Genetic Markers of Lung CancerLung CancerNCT00280202University of Pittsburgh6,000
已完成
不适用
Risk Communication in African American SmokersLung CancerNCT04084561Temple University166
已完成
2 期
Genetic Changes in Patients With Non-Small Cell Lung Cancer Who Are Receiving Vinorelbine and Gemcitabine Before SurgeryLung CancerNCT00057798Roswell Park Cancer Institute21
已完成
不适用
Genetic Epidemiology of Lung CancerLung CancerNCT00341835National Human Genome Research Institute (NHGRI)6,356