Acute Effects of Intermittent Respiratory Muscle Training and Hypoxia on Cardiovascular and Sleep Parameters in Elderly Persons With Prehypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Change in blood pressure in mmHg
研究概览
简要总结
The prevalence of pre-hypertension and hypertension in the elderly is very high. Apart from medication, physical exercise training is a potential strategy to reduce blood pressure, however, the ability to perform exercise can be limited in the elderly. Hence, alternative non-pharmacological strategies to reduce blood pressure are necessary. Two interventions that have been shown to positively influence blood pressure are respiratory muscle training (RMT) and intermittent hypoxia (IH). Whether a combination of RMT and IH yields even better effects is currently unknown. Therefore, in this study, the effect of a single session of RMT with and without IH on blood pressure and associated cardiovascular parameters will be investigated in elderly subjects with pre-hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 65-80 years
- •Systolic blood pressure between 130-139 mmHg and diastolic blood pressure lower than 90 mmHg
- •Non smoking
- •Normal Body-Mass-Index (BMI): 18.5-24.9 kg·m-2
- •Normal Lung Function
- •Willing to adhere to the general study rules
排除标准
- •Known or suspected non-compliance, drug or alcohol abuse
- •Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
- •Previous enrolment into the current study
- •Enrolment of the investigator, his/her family members, employees and other dependent persons
- •Intake of blood pressure medication
- •Intake of medications affecting sleep or the performance or the respiratory, cardiovascular or neuromuscular system
- •Acute or chronic illness other than prehypertension
研究组 & 干预措施
Study Group
干预措施: RMT (Procedure)
Study Group
干预措施: RMT + IH (Procedure)
Study Group
干预措施: Control (Procedure)
结局指标
主要结局
Change in blood pressure in mmHg
时间窗: At baseline after 20 min of lying in a supine position, every 5 minutes during the 60 min intervention, and 20, 35 and 50 min after the end of the intervention
Blood pressure before, during, and after each intervention measured with an automated sphygmomanometer
次要结局
- Change in cardiac output in L/min(At baseline after 15min of lying in a supine position, every 5 minutes during the 60 min intervention, and 15, 30 and 45 min after the end of the intervention)
- Change in heart rate variability in ms(At baseline after 15min of lying in a supine position, every 5 minutes during the 60 min intervention, and 15, 30 and 45 min after the end of the intervention)
- Changes in baroreflex sensitivity in ms/mmHg(At baseline after 15min of lying in a supine position, and 15, 30 and 45 min after the end of the intervention)
- Change in sleep efficiency defined as the ratio of total sleep time and time in bed(Continuously during the night following each intervention, from time to bed until wake up time in the morning (i.e. on average approximately 8hours))
- Change in pulse wave velocity in m/s(At baseline after 25 min of lying in a supine position, and 25, 40 and 55 min after the end of the intervention)
- Change in total peripheral resistance in dyn x s/cm^5(At baseline after 15min of lying in a supine position, every 5 minutes during the 60 min intervention, and 15, 30 and 45 min after the end of the intervention)
- Change in peripheral oxygenation during sleep in %Saturation(Continuously during the night following each intervention, from time to bed until wake up time in the morning (i.e. on average approximately 8hours))
- Change in subjective sleep quality(Within 5 minutes after waking-up following the night after each intervention)